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Quantomix WETSEM™ Technology

Electron Microscopy (EM) is a prime tool for high-resolution imaging, which has been the cornerstone of our understanding of living organisms and our material environment.

Because EM requires samples to be placed in a vacuum, it does not lend itself for use with wet samples. In the 50 years since its development, this drawback has been a major impediment in the use of EM for biomedical research, and for many clinical and industrial applications.

Light Microscopy, on the other hand, requires only minimal sample preparation. However, the resolution of light microscopy is limited to a few hundreds nanometers.

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The revolutionary technology of QuantomiX solves the problem of preparing wet samples for high-resolution imaging. It closes the resolution gap between conventional electron microscopy and light microscopy and offers the convenient sample preparation of light microscopy.
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For the first time, rapid and routine EM imaging of biological samples in a wet environment is now possible without the artifacts normally associated with sample preparation.

Image Gallery

Wet Corneal Endothelial Cells

Wet Mucosal Surface
of Intestines


Glomerulus in
Rat Kidney
Click on the images to see enlarged view

Advantage

  • Direct imaging of wet samples (food, cosmetics, inks, cells, tissues)
  • Compositional analysis of wet samples by X-ray microanalysis
  • Wide spectrum of staining and labeling capabilities for cells and tissues
  • Ability to image unstained or unfixed cells and tissues
  • Imaging of both adherent and non-adherent cells
  • High resolution histopathology
  • Intracellular imaging in a scanning EM
  • Imaging the entire cell surface
  • Excellent preservation and imaging of lipid structures
  • Easy-to-automate sample processing and imaging
  • Applications

  • Lipid Imaging and Analysis
  • Imaging lipid bodies in fully-wet cells and tissues
  • EDS of wet samples with QX capsules
  • Particle analysis in fully-wet conditions
  • Experimental Biology: subcellular organelles, cytoskeleton and motility,
        cell contacts, receptor distribution, extracellular matrix, tissue analysis
  • Industrial applications: food, oils, dyes, pharmaceuticals
  • Pathogen characterization
  • Clinical diagnosis: Histopathology, cytology, oncology
  • Tissue engineering, implants and prostheses
  • Environmental and toxicological applications

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